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Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.8K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Sensory Functions of the Skin01:16

Sensory Functions of the Skin

8.0K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

3.2K
Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Related Experiment Video

Updated: Jan 23, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

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Skin Cancer: Melanoma.

Luis Liu Pérez1, Benjamin Bashline

  • 1Grand Lake Family Practice and Pediatrics, 801 Pro Dr D, Celina, OH 45822.

FP Essentials
|June 13, 2019
PubMed
Summary

Melanoma, a dangerous skin cancer, is linked to UV exposure and sunburns. Early detection using ABCDE criteria and prompt biopsy are crucial for effective management and improved patient outcomes.

Area of Science:

  • Oncology
  • Dermatology
  • Public Health

Background:

  • Melanoma is the deadliest skin cancer, with intense UV radiation exposure as a primary risk factor.
  • Sunburn history and suspicious lesions necessitate primary care clinician awareness and patient monitoring.
  • The ABCDE criteria (Asymmetry, Borders, Color, Diameter, Evolution) aid in identifying potentially cancerous moles.

Purpose of the Study:

  • To outline the recognition, diagnosis, and management of melanoma for primary care clinicians.
  • To emphasize the importance of early detection and appropriate treatment pathways for melanoma patients.
  • To highlight the role of multidisciplinary care and lifelong follow-up in melanoma management.

Main Methods:

  • Utilizing ABCDE criteria for suspicious lesion assessment.

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The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
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The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

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Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging
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Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging

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Related Experiment Videos

Last Updated: Jan 23, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

16.5K
The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
11:02

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

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Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging
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Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging

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  • Employing dermatoscopy for enhanced diagnostic accuracy.
  • Recommending excisional biopsy over incisional biopsy for suspected melanoma.
  • Describing surgical excision, sentinel lymph node biopsy, targeted therapy, and immunotherapy based on melanoma stage.

    • Main Results:

    • Early detection through ABCDE criteria and dermatoscopy improves diagnostic yield.
    • Excisional biopsy is the preferred method for diagnosing melanoma.
    • Staging dictates treatment, ranging from surgical excision for early stages to combination therapy for metastatic disease.
    • Multidisciplinary management and regular follow-up are essential for all melanoma patients.

    Conclusions:

    • Primary care clinicians must be adept at recognizing melanoma using ABCDE criteria.
    • Prompt diagnosis and appropriate staging are critical for effective melanoma treatment.
    • Lifelong annual skin examinations are recommended for all patients with a history of melanoma (Stage IA-IV).