Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.8K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.8K
Laminins are the Adhesive Proteins of Basal Lamina00:55

Laminins are the Adhesive Proteins of Basal Lamina

3.1K
Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
3.1K
Basal Lamina are the Specialized Form of ECM01:03

Basal Lamina are the Specialized Form of ECM

3.7K
The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...
3.7K
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

3.0K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
3.0K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

3.0K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.0K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.2K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Skin Cancer: Melanoma.

FP essentials·2019
Same author

Skin Cancer: Precancers.

FP essentials·2019
Same author

Skin Cancer: Prevention.

FP essentials·2019
Same author

Cutaneous metastasis of endometrial carcinoma: an unusual and dramatic presentation.

Cutis·2019
Same author

A Case of a Cellular Neurothekeoma Presenting with Headaches and Review of the Literature.

Dermatopathology (Basel, Switzerland)·2016
Same author

Disseminated botryomycosis: a rare presentation.

Journal of drugs in dermatology : JDD·2014

Related Experiment Video

Updated: Jan 23, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

772

Skin Cancer: Squamous and Basal Cell Carcinomas.

Benjamin Bashline

    FP Essentials
    |June 13, 2019
    PubMed
    Summary

    Nonmelanoma skin cancers (NMSCs), primarily basal cell carcinoma and squamous cell carcinoma, are common but highly treatable. Early detection through regular skin exams and sun protection significantly improves outcomes for these UV-related skin cancers.

    Area of Science:

    • Dermatology
    • Oncology

    Background:

    • Nonmelanoma skin cancers (NMSCs) affect a significant portion of the American population.
    • Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) are the most prevalent types of NMSC.

    Purpose of the Study:

    • To provide an overview of NMSC epidemiology, risk factors, diagnosis, treatment, and prevention.
    • To emphasize the generally favorable prognosis and recommended follow-up care for NMSC patients.

    Main Methods:

    • Review of epidemiological data and established clinical guidelines for NMSC.
    • Description of diagnostic methods including biopsy and histological subtyping.
    • Summary of surgical and nonsurgical treatment modalities.

    Main Results:

    More Related Videos

    Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
    10:43

    Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

    Published on: December 23, 2022

    4.0K
    Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
    07:53

    Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

    Published on: March 17, 2020

    7.7K

    Related Experiment Videos

    Last Updated: Jan 23, 2026

    Development of Compendium for Esophageal Squamous Cell Carcinoma
    03:36

    Development of Compendium for Esophageal Squamous Cell Carcinoma

    Published on: April 12, 2024

    772
    Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
    10:43

    Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

    Published on: December 23, 2022

    4.0K
    Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
    07:53

    Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

    Published on: March 17, 2020

    7.7K
  • Solar UV radiation is the primary risk factor for NMSC, with fairer skin types and immunocompromise increasing susceptibility.
  • Biopsy is crucial for diagnosis, while treatment varies from surgical excision to topical or photodynamic therapies.
  • Prognosis for NMSC is excellent due to a low risk of metastasis.

    • Conclusions:

    • NMSC is highly curable, with prevention strategies focusing on sun safety and avoiding tanning beds.
    • Annual skin examinations are recommended for NMSC patients.
    • Prompt diagnosis and appropriate treatment lead to favorable outcomes.