A modular laboratory course using planarians to study genes involved in tissue regeneration

Area of Science:

• Developmental Biology
• Genetics
• Molecular Biology

Background:

• Undergraduate research offers valuable scientific engagement but faces limitations in scale at large institutions.
• A modular course-based undergraduate research experiences (CURE) model was developed to broaden student participation.

Purpose of the Study:

• To integrate authentic research into a modular laboratory course focused on planarian regeneration.
• To enhance students' scientific skills, critical thinking, and communication abilities.

Main Methods:

• Students identified and cloned genes involved in planarian biology.
• Gene expression patterns were determined using in situ hybridization.
• Gene function in regeneration was examined through experimental manipulation.

Main Results:

• Students successfully generated high-quality primary data and achieved course learning outcomes.
• Participants developed practical research skills, including experimental troubleshooting and literature analysis.
• Students demonstrated increased confidence and proficiency in independent scientific research.

Conclusions:

• The modular CURE model effectively accommodates a larger number of students in authentic research.
• The course fosters critical thinking, scientific communication, and practical research competencies.
• This adaptable course design can be implemented across diverse educational settings to enhance undergraduate science education.