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Neurodevelopmental Outcomes Comparing Bevacizumab to Laser for Type 1 ROP

Sarah Hilkert Rodriguez, Colleen Peyton, Katherine Lewis

    Ophthalmic Surgery, Lasers & Imaging Retina
    |June 25, 2019
    PubMed

    Insights

    Intravitreal bevacizumab (IVB) treatment for retinopathy of prematurity (ROP) showed no significant differences in major neurodevelopmental outcomes compared to laser therapy. However, IVB may offer protection against vision loss.

    Area of Science:

    • Ophthalmology
    • Neurodevelopmental Pediatrics
    • Neonatal Care

    Background:

    • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
    • Treatment modalities for ROP include laser photocoagulation and intravitreal bevacizumab (IVB).
    • Evaluating long-term neurodevelopmental outcomes is crucial for assessing the impact of ROP treatments.

    Purpose of the Study:

    • To compare neurodevelopmental outcomes in infants treated for ROP with laser versus primary intravitreal bevacizumab (IVB).
    • To identify factors associated with cerebral palsy (CP) in infants treated for ROP.
    • To assess the impact of ROP treatment on visual impairment and cognitive development.

    Main Methods:

    • Retrospective chart review of infants treated for ROP.
    • Comparison of primary outcomes: death, hearing loss, bilateral visual impairment (BVI), and cerebral palsy (CP).
    • Calculation of odds ratios (ORs) for CP and analysis of Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) scores.

    Main Results:

    • No significant differences in overall primary outcomes between laser and IVB treatment groups.
    • Adjusted odds of BVI were significantly higher with laser treatment compared to IVB (OR = 13.1; P = .038).
    • Hydrocephalus and BVI were strongly correlated with CP; IVB was not associated with CP.

    Conclusions:

    • Intravitreal bevacizumab (IVB) treatment for ROP was not associated with severe developmental disabilities.
    • IVB may provide a protective effect against vision loss in infants treated for ROP.
    • Visual outcomes are integral to neurodevelopmental assessment in ROP patients.
    Abstract

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