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Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis
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RIFM fragrance ingredient safety assessment, methyl 2-nonenoate, CAS Registry Number 111-79-5.
A M Api1, F Belmonte1, D Belsito2
1Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
Summary
Methyl 2-nonenoate safety was assessed for multiple endpoints. The chemical is not expected to be genotoxic, a sensitizer, or phototoxic, supporting its current use.
Area of Science:
- Chemical safety assessment
- Toxicology
- Environmental risk evaluation
Background:
- Methyl 2-nonenoate is used in various applications.
- Comprehensive safety data is crucial for regulatory compliance and consumer protection.
Purpose of the Study:
- To evaluate the safety of Methyl 2-nonenoate across multiple toxicological and environmental endpoints.
- To determine if current usage levels pose any risks to human health or the environment.
Main Methods:
- Genotoxicity assessed via read-across from ethyl trans-2,cis-4-decadienoate.
- Toxicity endpoints (repeated dose, reproductive, local respiratory) evaluated using Threshold of Toxicological Concern (TTC).
- Skin sensitization evaluated using data from target and read-across analog isobutyl-2-butenoate.
- Phototoxicity/photoallergenicity assessed using data and UV spectra.
- Environmental safety evaluated against IFRA Environmental Standards, including PBT assessment and risk quotients (PEC/PNEC).
Main Results:
- Methyl 2-nonenoate is not expected to be genotoxic based on read-across data.
- Exposure levels are below the TTC for repeated dose, reproductive, and local respiratory toxicity.
- No indication of skin sensitization potential.
- Methyl 2-nonenoate is not expected to be phototoxic or photoallergenic.
- The material is not considered Persistent, Bioaccumulative, and Toxic (PBT), with risk quotients <1.
Conclusions:
- The safety assessment supports the current use of Methyl 2-nonenoate.
- Methyl 2-nonenoate demonstrates a favorable safety profile for human health and the environment.
- No significant risks identified for genotoxicity, systemic toxicity, sensitization, phototoxicity, or environmental persistence.
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