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Updated: Jan 23, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
Published on: April 19, 2015
Improvement of the Firocoxib Dissolution Performance Using Electrospun Fibers Obtained from Different
Lauretta Maggi1, Valeria Friuli2, Enrica Chiesa3
1Department of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy. lauretta.maggi@unipv.it.
Abstract:
An electrospinning process was optimized to produce fibers of micrometric size with different combinations of polymeric and surfactant materials to promote the dissolution rate of an insoluble drug: firocoxib. Scanning Electron Microscopy (SEM) showed that only some combinations of the proposed carrier systems allowed the production of suitable fibers and further fine optimization of the technique is also needed to load the drug. Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) suggest that the drug is in an amorphous state in the final product. Drug amorphization, the fine dispersion of the active in the carriers, and the large surface area exposed to water interaction obtained through the electrospinning process can explain the remarkable improvement in the dissolution performance of firocoxib from the final product developed.
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