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Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus
Tao Wang1, Yongjun Mei1, Zhijun Li1
1Department of Rheumatology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
Abstract:
Systemic lupus erythematosus (SLE) is a chronic, systemic, autoimmune inflammatory disease characterized by the production of numerous autoantibodies and cytokines, as well as multiple organ damage. Specific B cell subsets negatively regulate immune responses and have been termed regulatory B cells (Bregs). Bregs are characterized by the production of the immunoregulatory cytokines interleukin (IL)-10, IL-35, and transforming growth factor (TGF)-β. Bregs suppress other immune cells through the secretion of these immunosuppressive cytokines and have thus been studied extensively for their potential role in the treatment of various autoimmune diseases. The progress of the research on Bregs and SLE in recent years is reviewed in this paper.
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