Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.2K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.5K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.5K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

9.9K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
9.9K
Communication01:03

Communication

8.7K
Communication between two animals occurs when one animal transmits an information signal that causes a change in the animal that receives the information. Organisms communicate with one another in a host of different ways. Signals can be auditory, chemical, visual, tactile, or a combination of these. Communication is a critical behavioral adaptation that promotes survival, growth, and reproduction.
8.7K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

2.9K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
2.9K
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

14.3K
Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
14.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping and engineering the human cell-cell interactome.

Nature biotechnology·2026
Same author

Programmable pathway profiles reveal signaling principles of TGF-β superfamily receptors.

bioRxiv : the preprint server for biology·2026
Same author

Discovering what is possible: How synthetic biology illuminates development.

Cell systems·2026
Same author

Integrative vasculogenesis unifies distinct endothelial sources in the developing lung.

bioRxiv : the preprint server for biology·2026
Same author

Genome-wide chromatin recording resolves dynamic cell state changes.

bioRxiv : the preprint server for biology·2026
Same author

A tissue-scale strategy for sensing threats in barrier organs.

Cell systems·2026
Same journal

PBX-dependent and -independent Hox programs establish and maintain motor neuron terminal identity.

Development (Cambridge, England)·2026
Same journal

NUDT21 regulates 3'UTR dynamics in epididymal principal cells to preserve sperm integrity.

Development (Cambridge, England)·2026
Same journal

Cell size control emerges from the vein-dependent coordinated divisions of distinct cell groups in Drosophila wing.

Development (Cambridge, England)·2026
Same journal

The people behind the papers - Kaoru Sugimura.

Development (Cambridge, England)·2026
Same journal

The people behind the papers - Zhainib Amir-Ugokwe and Kristy Red-Horse.

Development (Cambridge, England)·2026
Same journal

In preprints: toward a holistic lineage-tracing map of mammalian embryogenesis.

Development (Cambridge, England)·2026
See all related articles

Related Experiment Video

Updated: Jan 22, 2026

Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation
11:27

Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation

Published on: December 8, 2018

8.5K

Communication codes in developmental signaling pathways.

Pulin Li1,2, Michael B Elowitz3,4

  • 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Development (Cambridge, England)
|June 29, 2019
PubMed
Summary
This summary is machine-generated.

Scientists are uncovering how a few core cell signaling pathways achieve precise communication in development. They are deciphering "communication codes" in ligand identity, concentration, and dynamics for multicellular development.

Keywords:
Communication codesPathway architectureSignal processing

More Related Videos

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

8.4K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.9K

Related Experiment Videos

Last Updated: Jan 22, 2026

Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation
11:27

Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation

Published on: December 8, 2018

8.5K
The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

8.4K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.9K

Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Systems Biology

Background:

  • Multicellular development relies on precise cell-cell communication.
  • A limited set of intercellular signaling pathways must generate diverse developmental outcomes.
  • The mechanisms by which signaling pathways achieve specificity remain largely unknown.

Purpose of the Study:

  • To review recent advances in understanding cell-cell communication codes in development.
  • To explore how signaling pathways sense, transform, and distribute information.
  • To discuss the implications of these codes for developmental processes.

Main Methods:

  • Review of recent literature on intercellular signaling pathways.
  • Analysis of single-cell studies and cell-based reconstitution experiments.
  • Focus on the discovery and characterization of 'communication codes'.

Main Results:

  • Identification of 'communication codes' based on ligand identity, concentration, combinations, and dynamics.
  • Understanding how signaling pathways interpret these codes.
  • Insights into how pathways control spatial signaling distribution in multicellular contexts.

Conclusions:

  • A small set of core signaling pathways can generate complex developmental specificity through sophisticated 'communication codes'.
  • These codes are crucial for deciphering and transmitting developmental information.
  • Understanding these codes has broad implications for diverse developmental processes.