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Updated: Jan 22, 2026

Gold Nanoparticle Synthesis
Published on: July 10, 2021
Benzosultam Synthesis by Gold(I)-Catalyzed Ammonium Formation/Nucleophilic Substitution
Romain Pertschi1, Jean-Marc Weibel1, Patrick Pale1
1Laboratoire de Synthèse, Réactivité Organiques et Catalyse, Institut de Chimie, UMR 7177 - CNRS , Université de Strasbourg , 4 rue Blaise Pascal , 67070 Strasbourg , France.
Abstract:
The synthesis of benzosultams has been achieved through a gold(I)-catalyzed ammonium formation strategy. Starting from easily available N-(2-alkynyl)phenylsulfonyl azetidine derivatives, a cyclization reaction generated a spiroammonium gold intermediate that was ring-opened by nucleophilic alcohol or indole. This new methodology is compatible with the large variation in the substrates and nucleophiles and allowed the formation of benzosultams in high yield (18-98%, 20 examples). This strategy also allowed the preparation of benzosultam analogs via iododeauration and subsequent cross-coupling reactions.
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