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Published on: October 8, 2012
A case of S-100-negative CD1a-positive indeterminate cell histiocytosis
Sima Amin1, Jordan Jamerson2, Ronald G Tee3
1Texas A&M Health Sciences Center, College Station, Texas.
Abstract:
Histiocytoses are a group of rare disorders characterized by a proliferation of monocytes/macrophages and dendritic cells. We present a case of a 3-year-old girl with a diffuse papular eruption without systemic symptoms demonstrating a proliferation of strongly CD1a+ histiocytes, but negative for S-100 and langerin on histopathology. Systemic work-up including bone marrow biopsy was unremarkable, and the patient received a diagnosis of CD1a+ S- 100-indeterminate cell histiocytosis.
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