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IL-10 gene polymorphism in diabetic retinopathy.
1Department of Ophthalmology, The First Affiliated Hospital of Xiamen University & Teaching Hospital of Fujian Medical University, Xiamen, China. praq43@163.com.
European Review for Medical and Pharmacological Sciences
|July 13, 2019
Summary
The interleukin-10 (IL-10) gene polymorphism rs11567245 is associated with diabetic retinopathy (DR) development and clinical indicators. However, rs1145612 showed no correlation with DR.
Area of Science:
- Genetics
- Ophthalmology
- Endocrinology
Background:
- Diabetic retinopathy (DR) is a major complication of diabetes mellitus.
- The role of interleukin-10 (IL-10) gene polymorphisms in DR pathogenesis requires further investigation.
Purpose of the Study:
- To explore the association between IL-10 gene promoter polymorphisms (rs1145612 and rs11567245) and the development of diabetic retinopathy.
- To determine if specific IL-10 gene variants correlate with clinical indicators in DR patients.
Main Methods:
- A cohort of 420 diabetes patients were categorized into non-DR (n=200) and DR (n=220) groups based on fundus examination.
- Single nucleotide polymorphisms (SNPs) rs1145612 and rs11567245 in the IL-10 gene promoter were genotyped using conformational differential gel electrophoresis.
Main Results:
- No significant association was observed between IL-10 rs1145612 polymorphism and DR or its clinical parameters.
- IL-10 rs11567245 polymorphism demonstrated a significant correlation with multiple clinical indicators, including BMI, SBP, BUN, FBG, and 2hBG (p<0.05).
Conclusions:
- The IL-10 gene promoter polymorphism rs1145612 is not implicated in the occurrence or progression of DR.
- The IL-10 gene promoter polymorphism rs1145612 is implicated in the occurrence and progression of DR, suggesting its potential role in disease pathogenesis and management.
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