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Myocardial oxygen tension during left ventricular bypass
Y Mitamura1, T Matsumoto, T Mikami
1Department of Medical Electronics, Research Institute of Applied Electricity, Hokkaido University, Sapporo, Japan.
Advances in Experimental Medicine and Biology
|January 1, 1988
Summary
Left ventricular assist devices (LVADs) improve myocardial oxygen supply and reduce carbon dioxide levels. However, LVADs decrease coronary sinus blood flow, indicating potential regional impacts on the heart.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
- Physiology
Background:
- Myocardial gas tensions are key indicators of oxygen supply and consumption balance.
- Left ventricular assist devices (LVADs) are used to support cardiac function.
Purpose of the Study:
- To evaluate the impact of an LVAD on myocardial gas tensions and coronary sinus blood flow (CSBF).
- To assess the regional myocardial effects of LVAD support in a canine model.
Main Methods:
- Implanted LVADs in dogs, creating left ventricular (LV) or left atrial (LA) bypass to the aorta.
- Monitored myocardial oxygen (PmO2) and carbon dioxide (PmCO2) tensions using mass spectrometry.
- Measured CSBF via an extracorporeal flow loop.
Main Results:
- LVAD support significantly increased PmO2 and decreased PmCO2 in the LV group.
- CSBF significantly decreased during LVAD bypass in both LV and LA groups.
- LVADs reduced LV pressure and increased diastolic arterial pressure, affecting coronary perfusion.
Conclusions:
- LVAD counterpulsation improves myocardial oxygenation and reduces metabolic waste.
- Reduced CSBF during LVAD support warrants further investigation into regional myocardial perfusion.
- LVADs alter hemodynamic parameters, impacting the balance of myocardial oxygen supply and demand.