GUIDED REGENERATION OF JAW BONE DEFECTS WITH COMBINATION OF OSTEOPLASTIC MATERIALS AND STEM CELLS

Area of Science:

• Maxillofacial Surgery
• Regenerative Medicine
• Biomaterials Science

Background:

• Mandibular defect reconstruction presents significant challenges in maxillofacial surgery.
• Successful bone regeneration is often hindered by infection, impaired microcirculation, and tissue hypoxia.
• Current treatments require improved methods for effective bone tissue repair.

Purpose of the Study:

• To evaluate the efficacy of combining osteoplastic material with bone marrow-derived mesenchymal stem cells for mandibular bone defect regeneration.
• To compare the regenerative potential of this combination against untreated defects and defects treated with osteoplastic material alone.
• To demonstrate the advantages of this combined approach in improving bone defect healing.

Main Methods:

• Creation of mandibular bone defects in laboratory rats.
• Experimental groups included: no treatment, osteoplastic material (BIO-OSS) only, and BIO-OSS infiltrated with mesenchymal stem cells.
• Comparative analysis using observational, histochemical, and X-ray methods over a 6-month period.

Main Results:

• The combination of osteoplastic material and mesenchymal stem cells promoted increased formation of red bone marrow compared to natural regeneration.
• Histochemical and X-ray analyses indicated enhanced bone regeneration in the group treated with the combined therapy.
• Significant improvements in bone defect osteointegration and regenerated bone tissue quality were observed.

Conclusions:

• The combination of osteoplastic material and bone marrow-derived mesenchymal stem cells offers a superior approach for mandibular bone defect regeneration.
• This method accelerates the osteointegration process and enhances the quality of newly formed bone tissue.
• The findings suggest a promising therapeutic strategy for improving outcomes in maxillofacial reconstructive surgery.