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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
Published on: September 20, 2019
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Cutaneous spindle cell adenolipoma with eccrine and apocrine differentiation
1Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.
Journal of Cutaneous Pathology
|July 23, 2019
Summary
Cutaneous spindle cell adenolipoma (SCAL) is a rare skin tumor. This case highlights its unique features, including extensive eccrine and apocrine glands, supporting a hamartomatous origin.
Area of Science:
- Dermatopathology
- Surgical Pathology
Background:
- Cutaneous spindle cell adenolipoma (SCAL) is a rare lipoma variant.
- Only 11 cases have been reported previously.
Observation:
- A 77-year-old male presented with a nasolabial nodule misdiagnosed by an outside pathologist.
- The tumor contained mature adipocytes, spindle cells (CD34+), collagen, and numerous eccrine/apocrine glands.
Findings:
- The histological features confirmed the diagnosis of cutaneous spindle cell adenolipoma.
- Spindle cells were negative for S100 protein and SOX10.
- The extensive glandular component, with both eccrine and apocrine differentiation, is a novel finding.
Implications:
- This case supports a hamartomatous etiology for SCAL.
- Recognizing SCAL is crucial to avoid misdiagnosis with other cutaneous lesions.
- This finding expands the understanding of SCAL's histopathological spectrum.
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