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Updated: Jan 21, 2026
09:04
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
10.1K
Pivotal micro factors associated with endothelial cells
Ling-Bing Meng1, Yuan-Meng Zhang2, Meng-Jie Shan3
1Department of Neurology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Chinese Medical Journal
|July 24, 2019
Summary
Micro factors significantly influence endothelial cell (EC) functions. Vascular endothelial growth factor (VEGF) and angiogenin (ANG) are key mediators, impacting ECs in physiological and pathological conditions, particularly in inflammatory diseases.
Area of Science:
- Cell Biology
- Molecular Biology
- Pathophysiology
Background:
- Endothelial cells (ECs) are crucial for biological functions.
- Micro factors significantly influence EC activity and behavior.
- Vascular endothelial growth factor (VEGF) and angiogenin (ANG) are key micro factors regulating ECs.
Purpose of the Study:
- To review the role of micro factors in endothelial cell biology.
- To summarize the pathophysiological mechanisms and pathways involving micro factors and ECs.
- To identify key micro factors and their associated biological processes.
Main Methods:
- Extensive literature search in PubMed (2007-2018).
- Keywords: "micro factors" and "endothelial cell."
- Inclusion of original articles, reviews, and other relevant research.
Main Results:
- VEGF and ANG are critical for EC occurrence, development, and pathological status.
- Other identified micro factors include IL-10, p53, NF-κB, IL-6, and TNF.
- Gene Ontology and KEGG analyses revealed enrichment in transcription regulation, cellular responses, apoptosis, and inflammatory diseases.
Conclusions:
- VEGF and ANG are primary mediators influencing ECs.
- The impact of micro factors on ECs is complex and multifaceted.
- This review consolidates current understanding of EC-micro factor correlations.
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