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Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel

Bolin Jing1,2, Gong Cheng1, Jianjun Li3

  • 1State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

Marine Drugs
|July 25, 2019
PubMed

Insights

Partially acetylated chitooligosaccharides (paCOS) show potential against liver cancer metastasis. This study investigated paCOS

Area of Science:

  • Biochemistry
  • Oncology
  • Biomaterials

Background:

  • Chitooligosaccharides (COS) exhibit anti-tumor properties.
  • The specific anti-metastatic mechanisms of COS remain largely unexplored.
  • Partially acetylated COS (paCOS) presents a novel therapeutic avenue.

Purpose of the Study:

  • To investigate the effects of paCOS (FA = 0.46) on distinct phases of liver cancer cell metastasis.
  • To elucidate the targeted stages of tumor metastasis by paCOS.
  • To evaluate paCOS efficacy using a dynamic tumor-vessel microsystem.

Main Methods:

  • Utilized a dynamic tumor-vessel microsystem simulating physiological flow.
  • Assessed paCOS effects on HepG2 cell proliferation, migration, invasion, and adhesion.
  • Investigated paCOS impact on tumor vascular growth and barrier function.

Main Results:

  • paCOS (FA = 0.46) inhibited HepG2 cell proliferation via vascular absorption.
  • paCOS suppressed HepG2 cell migration by inhibiting pseudopod formation.
  • paCOS demonstrated differential effects on invasion, vascular growth, and cell adhesion, with 10 μg/mL showing stronger invasion inhibition and 100 μg/mL impacting vascular integrity.

Conclusions:

  • paCOS (FA = 0.46) effectively targets multiple stages of liver cancer metastasis.
  • paCOS exhibits significant anti-metastatic potential, warranting further drug development.
  • The study highlights the therapeutic promise of paCOS in combating cancer spread.
Keywords:
dynamic tumor-vessel microsystemliver tumor cell metastasispartially acetylated chitooligosaccharides

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