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Updated: Jan 21, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Enantioselective Synthesis of Arene cis-Dihydrodiols from 2-Pyrones
Xiao-Wei Liang1, Yunlong Zhao1, Xu-Ge Si1
1Department of Chemistry and Research Center for Molecular Recognition and Synthesis, Fudan University, 220 Handan Rd., Shanghai, 200433, China.
Abstract:
An enantioselective chemical synthesis of arene cis-dihydrodiols has been realized from 2-pyrones through sequential ytterbium-catalyzed asymmetric inverse-electron-demand Diels-Alder (IEDDA) reaction of 2-pyrones and retro-Diels-Alder extrusion of CO2 . By using this strategy, a series of substituted arene cis-dihydrodiols can be obtained efficiently with high enantioselectivity (>99 % ee in many cases). Based on this strategy, efficient and concise asymmetric total syntheses of (+)-MK7607 and 1-epi-(+)-MK7607 were accomplished.
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