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Updated: Jan 21, 2026

Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry
Published on: April 3, 2019
Mass Spectrometry-Based Tissue Imaging of Small Molecules
Carly N Ferguson1, Joseph W M Fowler1, Jonathan F Waxer1
1Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA.
Abstract:
Mass spectrometry imaging (MSI) of tissue samples is a promising analytical tool that has quickly become associated with biomedical and pharmacokinetic studies. It eliminates several labor-intensive protocols associated with more classical imaging techniques, and provides accurate, histological data at a rapid pace. Because mass spectrometry is used as the readout, MSI can be applied to almost any molecule, especially those that are biologically relevant. Many examples of its utility in the study of peptides and proteins have been reported; here we discuss its value in the mass range of small molecules. We explore its success and potential in the analysis of lipids, medicinals, and metal-based compounds by featuring representative studies from mass spectrometry imaging laboratories around the globe.
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