The Impact of the Low Frequency of the Electromagnetic Field on Human

Recently, there has been attention and controversial debate topic about the effect of low-frequency electromagnetic fields (EMFs) on human beings. The catalyst for public awareness initiated from the first epidemiological study in 1979 that reported an association between residential EMFs exposure and the incidence of childhood leukemia. For over 40 years, many epidemiological and laboratory investigations were conducted to identify the possible biological effects of low-frequency EMF. Several studies conducted at frequencies 50/60 Hz, which related to generating of electricity from electrical appliances. Experimental studies on low-frequency EMF have provided conflicting data under specific "in vivo" and "in vitro" environments. Some original papers have reported the damaging effect on DNA molecule in EMF-exposed cells. Other studies have suggested no such damage in EMF-exposed cells. Also, the conclusions from other studies were inconclusive. These conflicting findings may attribute to the differences in the apparatus used to generate electromagnetic fields, experimental design, exposure time, genetic endpoints, and biological materials such as cell lines and animal species, strain, and age. As DNA damage is frequently a prerequisite for cancer disease, this review provided an experimental body of evidence on the effect of EMF on genetic material.