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Updated: Jan 21, 2026

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
Published on: June 27, 2022
Controlled release of hydrogen sulfide significantly reduces ROS stress and increases dopamine levels in transgenic
Rafat Ali1, Hilal Ahmad Pal1, Rohil Hameed2
1Department of Chemistry and Centre for Nanoscience, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India. sverma@iitk.ac.in.
Abstract:
Hydrogen sulfide, an endogenous signalling molecule, is central to several pathophysiological processes in mammalian systems. It scavenges reactive oxygen species and is known to ameliorate dopaminergic neuronal degeneration in neurotoxin-induced Parkinson's disease models. The rapid volatilization of H2S from spontaneously releasing sulfide salts being a challenge, we describe peptide conjugates which exhibit tris(2-carboxyethyl)phosphine mediated "slow and sustained" H2S release. These conjugates reduced hydrogen peroxide-induced oxidative stress and significantly increased dopamine levels in transgenic C. elegans.
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