Related Experiment Video
Updated: Jan 21, 2026
10:15
Rapid Depletion of Renal Macrophages Using Human CD59/Intermedilysin Cell Ablation Tool
Published on: May 9, 2025
677
Macrophages in Renal Fibrosis
Xiao-Ming Meng1, Thomas Shiu-Kwong Mak2, Hui-Yao Lan3
1School of Pharmacy, Anhui Medical University, Hefei, 230032, Anhui, China.
Advances in Experimental Medicine and Biology
|August 11, 2019
Summary
Monocytes and macrophages play a key role in kidney injury and fibrosis. Targeting their activation and polarization is crucial for developing effective renal fibrosis treatments.
Area of Science:
- Nephrology
- Immunology
- Cell Biology
Background:
- Monocytes and macrophages are central to renal injury, repair, and fibrosis in kidney diseases.
- These cells exhibit heterogeneity and plasticity, responding to the renal microenvironment during fibrotic processes.
Purpose of the Study:
- To elucidate the dual role of monocyte-derived macrophages in renal fibrotic diseases.
- To highlight the potential of targeting macrophage behavior for therapeutic interventions in renal fibrosis.
Main Methods:
- Review and synthesis of existing literature on monocyte/macrophage roles in renal pathology.
- Analysis of macrophage activation states (M1/M2) and their markers (e.g., CD11b, Ly6C) in renal fibrosis.
Main Results:
- Classically activated M1 macrophages (CD11b+/Ly6Chigh) exacerbate renal injury via pro-inflammatory factors.
- Alternatively activated M2 macrophages (CD11b+/Ly6Cintermediate) may aid repair but can promote fibrosis (CD11b+/Ly6Clow) through paracrine effects or macrophage-to-myofibroblast transition (MMT).
Conclusions:
- Macrophage polarization is a critical determinant of kidney injury, repair, and fibrosis progression.
- Therapeutic strategies focused on modulating monocyte/macrophage recruitment, activation, and polarization are essential for treating renal fibrosis.
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