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Updated: Jan 21, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
Published on: July 18, 2025
Lipid Metabolism Disorder and Renal Fibrosis
Xiao-Gang Du1, Xiong-Zhong Ruan2
1Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University of Medical Science, Chongqing, China.
Abstract:
Since the lipid nephrotoxicity hypothesis was proposed in 1982, increasing evidence has supported the hypothesis that lipid abnormalities contributed to the progression of glomerulosclerosis. In this chapter, we will discuss the general promises of the original hypothesis, focusing especially on the role of lipids and metabolic inflammation accompanying CKD in renal fibrosis and potential new strategies of prevention.
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