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Related Concept Videos

Contact-dependent Signaling01:19

Contact-dependent Signaling

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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
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Contact Angle01:13

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When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
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Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
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Electromotive Force02:36

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Electricity is generated by either electrons or ions flowing through a solution or a conducting medium. This flow of electrons or specifically electrical charge is defined as an electric current. When electrons move through a wire, they generate an electric current. It can be recalled  that in a redox reaction, electrons are lost and gained. In the spontaneous redox reaction of zinc  with copper, when zinc is immersed in a copper ion solution, a transfer of electrons from one substance to...
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Intermolecular forces (IMF) are electrostatic attractions arising from charge-charge interactions between molecules. The strength of the intermolecular force is influenced by the distance of separation between molecules. The forces significantly affect the interactions in solids and liquids, where the molecules are close together. In gases, IMFs become important only under high-pressure conditions (due to the proximity of gas molecules). Intermolecular forces dictate the physical properties of...
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Intermolecular Forces in Solutions02:28

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The formation of a solution is an example of a spontaneous process, a process that occurs under specified conditions without energy from some external source.
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Robotic Ablation of Atrial Fibrillation
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Robotic Ablation of Atrial Fibrillation

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Contact Force and Ablation Index.

Sohaib A Virk1, Richard G Bennett2, Ivana Trivic1

  • 1Department of Cardiology, Westmead Hospital, Westmead Applied Research Centre, University of Sydney, Sydney, Australia.

Cardiac Electrophysiology Clinics
|August 12, 2019
PubMed
Summary
This summary is machine-generated.

Contact force (CF)-sensing catheters aim to improve radiofrequency ablation for arrhythmias. While observational studies suggest benefits, randomized trials show no significant improvements in procedure time, complications, or recurrence rates with CF-guided ablation.

Keywords:
Ablation indexArrhythmiasAtrial fibrillationContact forceRadiofrequency ablation

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Area of Science:

  • Electrophysiology
  • Cardiovascular Interventions

Background:

  • Durable lesion formation is crucial for successful radiofrequency ablation of arrhythmias.
  • Catheter tip-tissue contact force (CF) directly impacts lesion quality, with implications for both complications and recurrence.
  • Emerging CF-sensing catheters offer real-time feedback on contact force during ablation procedures.

Purpose of the Study:

  • To evaluate the impact of CF-sensing catheters on radiofrequency ablation outcomes.
  • To compare CF-guided ablation with traditional methods in randomized controlled trials.

Main Methods:

  • Randomized controlled trials were conducted to assess the efficacy of CF-sensing catheters.
  • Key outcome measures included procedural duration, fluoroscopy exposure, complication rates, and arrhythmia recurrence.

Main Results:

  • Randomized controlled trials did not demonstrate a reduction in procedural durations or fluoroscopy exposure with CF-sensing catheters.
  • No significant decrease in the incidence of major complications was observed.
  • Long-term arrhythmia recurrence rates were not improved by using CF-guided ablation techniques.

Conclusions:

  • Despite technological advancements, current evidence from randomized trials does not support a significant benefit of CF-sensing catheters in improving ablation outcomes.
  • Further research may be needed to optimize the use of CF-sensing technology in managing cardiac arrhythmias.