Palladium-catalyzed multicomponent reactions: an overview

Area of Science:

• Organic Chemistry
• Catalysis
• Green Chemistry

Background:

• Multi-component reactions (MCRs) are efficient synthetic strategies.
• Palladium (Pd)-catalyzed reactions offer versatile synthetic routes.
• MCRs are atom-economic, environmentally friendly, and minimize by-products.

Purpose of the Study:

• To review developments in palladium-catalyzed multi-component reactions.
• To categorize these reactions based on the resulting product structures.
• To highlight the applications of Pd-catalyzed MCRs in various chemical fields.

Main Methods:

• Literature review of Pd-catalyzed MCRs up to 2019.
• Categorization of reactions by product type: acyclic, carbocyclic, heterocyclic, and miscellaneous compounds.
• Analysis of reaction mechanisms and scope.

Main Results:

• Comprehensive overview of advancements in Pd-catalyzed MCRs.
• Classification of reactions yielding diverse molecular architectures.
• Demonstration of MCRs' utility in synthesizing complex molecules.

Conclusions:

• Pd-catalyzed MCRs are powerful tools in modern organic synthesis.
• These reactions facilitate efficient construction of valuable compounds.
• Significant applications exist in medicinal chemistry and combinatorial synthesis.