Can we use Nature's Structure-Activity-Relationships to Make Better Drugs?

Kinetic Benefit(s) of Allosteric Receptor Blockade by Positive Allosteric Modulator Antagonists.

ACS pharmacology & translational science·2026

Receptor kinetics: Binding flux-based approaches offer complementary insight into how ligand binding evolves with time.

British journal of pharmacology·2026

Effects of diffusion, affinity, and permeation rate on drug cell therapy.

Journal of receptor and signal transduction research·2026

Biased Signaling as Allosteric Probe Dependence: Everything Old Is New Again.

Biochemistry·2026

Therapeutic implications of target residence time.

Current opinion in structural biology·2026

Structure-based design of an opioid receptor modulator for enhanced morphine analgesia.

Science advances·2026

Pharmacological targeting of GCN5/PCAF (KAT2A/B): Current drug discovery strategies and translational potential.

Drug discovery today·2026

Artificial intelligence agents and agentic artificial intelligence applied to precision medicine.

Drug discovery today·2026

China's drug discovery strategy: established targets, combination approaches, and small-molecule optimization.

Drug discovery today·2026

mRNA therapeutics for restoring immune tolerance in autoimmune diseases.

Drug discovery today·2026

Sustainable drug delivery systems: Biodegradable carriers for a carbon-neutral pharma future.

Drug discovery today·2026

Designing time-limited aryl hydrocarbon receptor drugs: A kinetic framework from the FICZ-CYP1A1 feedback axis.

Drug discovery today·2026

Prediction of bile salt export pump inhibition using biomimetic chromatographic descriptors: Integrating membrane affinity and protein binding.

ADMET & DMPK·2026

Facile synthesis of amorphous coordinated metal-drug frameworks for cancer immunotherapy.

Materials today. Bio·2026

Sex- and APOE-specific transcriptomic drug repurposing identifies four candidate therapeutics for Alzheimer's disease.

Alzheimer's & dementia (New York, N. Y.)·2026

Pharmacophore-guided computational profiling of thiadiazole-based therapeutic addressing flap necrosis: Molecular simulation, DFT mapping, pharmacokinetic and kinetic evaluation.

Computational biology and chemistry·2026

An HBT-based "off-on" fluorescent probe for direct detection of methyl parathion in environmental water and Chinese medicine samples.

RSC advances·2026

AI Structural Biology in Nephrology: Powerful Scaffolds, Fragile Certainties.

Journal of the American Society of Nephrology : JASN·2026

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Can we use Nature's Structure-Activity-Relationships to Make Better Drugs?

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Kinetic Benefit(s) of Allosteric Receptor Blockade by Positive Allosteric Modulator Antagonists.

Receptor kinetics: Binding flux-based approaches offer complementary insight into how ligand binding evolves with time.

Effects of diffusion, affinity, and permeation rate on drug cell therapy.

Biased Signaling as Allosteric Probe Dependence: Everything Old Is New Again.

Therapeutic implications of target residence time.

Structure-based design of an opioid receptor modulator for enhanced morphine analgesia.

Pharmacological targeting of GCN5/PCAF (KAT2A/B): Current drug discovery strategies and translational potential.

Artificial intelligence agents and agentic artificial intelligence applied to precision medicine.

China's drug discovery strategy: established targets, combination approaches, and small-molecule optimization.

mRNA therapeutics for restoring immune tolerance in autoimmune diseases.

Sustainable drug delivery systems: Biodegradable carriers for a carbon-neutral pharma future.

Designing time-limited aryl hydrocarbon receptor drugs: A kinetic framework from the FICZ-CYP1A1 feedback axis.

Prediction of bile salt export pump inhibition using biomimetic chromatographic descriptors: Integrating membrane affinity and protein binding.

Facile synthesis of amorphous coordinated metal-drug frameworks for cancer immunotherapy.

Sex- and APOE-specific transcriptomic drug repurposing identifies four candidate therapeutics for Alzheimer's disease.

Pharmacophore-guided computational profiling of thiadiazole-based therapeutic addressing flap necrosis: Molecular simulation, DFT mapping, pharmacokinetic and kinetic evaluation.

An HBT-based "off-on" fluorescent probe for direct detection of methyl parathion in environmental water and Chinese medicine samples.

AI Structural Biology in Nephrology: Powerful Scaffolds, Fragile Certainties.

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Can we use Nature's Structure-Activity-Relationships to Make Better Drugs?

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