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Updated: Jan 20, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Comparison between non-visualized polyps and visualized polyps on optical coherence tomography angiography in
Zongyi Zhan1, Limei Sun1, Chenjin Jin1
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510000, Guangdong, China.
Higher polyp height and overlying hemorrhage or retinal vessels, not size or pulsation, impact polyp visualization on optical coherence tomography angiography (OCTA) in polypoidal choroidal vasculopathy (PCV). This finding aids in understanding OCTA limitations for PCV diagnosis.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Polypoidal choroidal vasculopathy (PCV) is a significant cause of vision loss.
- Optical coherence tomography angiography (OCTA) is a key imaging modality for PCV, but polyp visualization can be inconsistent.
Purpose of the Study:
- To investigate the factors contributing to the non-visualization of polyps in patients with active PCV using en face OCTA.
- To identify specific characteristics of polyps that affect their detectability on OCTA.
Main Methods:
- A cross-sectional study included 30 eyes with treatment-naïve active PCV.
- Analysis involved fundus photography, fluorescein angiography (FFA), indocyanine green angiography (ICGA), SD-OCT, and en face OCTA.
- Comparison of visualized versus non-visualized polyps based on imaging features.
Main Results:
- Of 64 polyps identified by FFA/ICGA, 65.6% were visualized on OCTA, while 34.4% were not.
- Non-visualized polyps had significantly greater height on SD-OCT (243.95 µm vs. 188.00 µm).
- Factors like thick subretinal hemorrhage or retinal vessel proximity obscured polyps on OCTA.
Conclusions:
- Polyp height, not size or pulsation, is the primary determinant of OCTA visualization in PCV.
- Early ICGA pulsatile polyps and those obscured by hemorrhage or vessels are less likely to be visualized on OCTA.
- Understanding these limitations is crucial for accurate interpretation of OCTA in PCV management.
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