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Valproate in the treatment of rapid-cycling bipolar disorder
S L McElroy1, P E Keck, H G Pope
1Epidemiology Laboratory, McLean Hospital, Belmont, Massachusetts 02178.
Journal of Clinical Psychopharmacology
|August 1, 1988
Abstract:
Six consecutive patients with rapid-cycling bipolar disorder, refractory or only minimally responsive to treatment with lithium salts and neuroleptics, including five also refractory to carbamazepine, all demonstrated a moderate or marked response to the anticonvulsant valproate. These observations suggest that valproate may represent a promising treatment alternative in this often treatment-resistant form of bipolar disorder.