Related Experiment Video
Updated: Jan 20, 2026

A BW Reporter System for Studying Receptor-Ligand Interactions
Published on: January 7, 2019
Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies
Stephen Safe1, Huajun Han2,3,4, Jennifer Goldsby3,4
1Department of Veterinary Physiology and Pharmacology.
Abstract:
The aryl hydrocarbon receptor (AhR) binds structurally diverse ligands that vary from the environmental toxicant 2,3,7,8-tetrachlorodibenzo-B-dioxin (TCDD) to AhR- active pharmaceuticals and health-promoting phytochemicals. There are remarkable differences in the toxicity of TCDD and related halogenated aromatics (HAs) vs. health promoting AhR ligands, and genomic analysis shows that even among the toxic HAs, there are differences in their regulation of genes and pathways. Thus, like ligands for other receptors, AhR ligands are selective AhR modulators (SAhRMs) which exhibit variable tissue-, organ- and species-specific genomic and functional activities.
More Related Videos
Related Concept Videos
Internal Receptors
Ligand Binding and Linkage
Ligand Binding Sites
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Genomics
Nomenclature of Aryl and Heterocyclic Amines

