Related Experiment Video

Updated: Jan 20, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

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Current Updates on Trastuzumab Resistance in HER2 Overexpressing Breast Cancers

Aamir Ahmad1

  • 1Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA. aahmad@health.southalabama.edu.

Advances in Experimental Medicine and Biology
|August 29, 2019
PubMed

Insights

Trastuzumab is a key therapy for HER2-amplified breast cancer. Recent research explores epigenetic and non-coding RNA mechanisms driving acquired resistance to this vital treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Trastuzumab is a primary therapy for HER2-amplified breast cancer.
  • Despite its efficacy, acquired resistance remains a significant clinical challenge.
  • Recent FDA approvals highlight the ongoing importance of Trastuzumab and its variants.

Purpose of the Study:

  • To discuss recent advances in understanding acquired resistance to Trastuzumab.
  • To focus on epigenetic and non-coding RNA mechanisms contributing to treatment resistance.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of emerging research on epigenetic modifications.
  • Investigation of non-coding RNA's role in Trastuzumab resistance.

Main Results:

  • Acquired resistance to Trastuzumab is a complex process.
  • Epigenetic alterations play a crucial role in resistance development.
  • Non-coding RNAs are increasingly recognized as key mediators of resistance.

Conclusions:

  • Understanding epigenetic and non-coding RNA mechanisms is vital for overcoming Trastuzumab resistance.
  • Future therapeutic strategies may target these epigenetic and non-coding RNA pathways.
  • Continued research is needed to develop novel treatments for resistant HER2-positive breast cancer.
Keywords:
Breast cancerEpigeneticHER2Non-coding RNA · miRNATrastuzumab

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