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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

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Emerging Novel Therapeutics in Triple-Negative Breast Cancer

Tomas G Lyons1, Tiffany A Traina2,3

  • 1Breast Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. lyonst@mskcc.org.

Advances in Experimental Medicine and Biology
|August 29, 2019
PubMed

Insights

Triple-negative breast cancer (TNBC) is aggressive, lacking effective targeted therapies. This review highlights recent advances and novel targeted treatments for TNBC, addressing an unmet clinical need.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Breast cancer mortality is declining due to early detection and improved therapies.
  • Treatment varies by histological subtype, with effective targeted options for ER-positive and HER2-positive disease.
  • Triple-negative breast cancer (TNBC) is an aggressive subtype with limited targeted therapeutic options.

Purpose of the Study:

  • To review recent advances in the treatment of triple-negative breast cancer.
  • To emphasize emerging novel targeted therapies for TNBC.
  • To discuss the refinement of TNBC classification by molecular characteristics.

Main Methods:

  • Literature review of recent studies on TNBC treatment.
  • Analysis of emerging targeted therapies for TNBC.
  • Discussion of molecular subtyping and clinical response in TNBC.

Main Results:

  • TNBC is a heterogeneous subtype requiring tailored therapeutic strategies.
  • Novel targeted therapies are showing promise for TNBC treatment.
  • Molecular characterization is refining treatment approaches for TNBC.

Conclusions:

  • Advances in targeted therapies offer new hope for treating aggressive TNBC.
  • Further research into novel treatments is crucial for addressing the unmet needs in TNBC.
  • Personalized therapeutic strategies based on molecular profiles are key for TNBC management.
Keywords:
AKT inhibitorAndrogen receptorAntibody-drug conjugateCheckpoint inhibitorPARP inhibitorTargeted therapiesTriple-negative breast cancer

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