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Related Experiment Video

Updated: Jan 20, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

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Infectious Mononucleosis Management in Athletes.

Anthony S Ceraulo1, Jeffrey R Bytomski1

  • 1Department of Community and Family and Medicine, Duke University, Durham, NC, USA; Department of Orthopedics, Duke University, Durham, NC, USA.

Clinics in Sports Medicine
|September 2, 2019
PubMed
Summary
This summary is machine-generated.

Infectious mononucleosis, often caused by Epstein-Barr virus, requires standardized lab tests and return-to-play protocols in athletes. Serial ultrasounds aid in preventing splenic rupture, a serious complication.

Keywords:
AthleteInfectious mononucleosisReturn to playUltrasound

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Area of Science:

  • Sports Medicine
  • Infectious Diseases
  • Diagnostic Imaging

Background:

  • Infectious mononucleosis is prevalent in athletic settings, with Epstein-Barr virus causing over 90% of cases.
  • Current diagnostic and return-to-play protocols exhibit clinical variability.
  • Splenic rupture is a significant, albeit rare, complication.

Purpose of the Study:

  • To propose a systematic approach for laboratory evaluation and return-to-play decisions in infectious mononucleosis.
  • To reduce clinical variation in managing athletes with infectious mononucleosis.
  • To highlight the role of serial ultrasonography in assessing splenic integrity.

Main Methods:

  • Review of clinical guidelines and literature on infectious mononucleosis management in athletes.
  • Analysis of diagnostic laboratory workup variations.
  • Evaluation of return-to-play criteria and the utility of serial ultrasonography.

Main Results:

  • A standardized laboratory workup can improve diagnostic consistency.
  • A systematic approach to return-to-play decisions can minimize variability.
  • Serial ultrasonography has demonstrated utility in guiding return-to-play decisions by monitoring spleen status.

Conclusions:

  • Standardized protocols for diagnosis and return-to-play are essential for athletes with infectious mononucleosis.
  • Minimizing clinical variation through systematic approaches enhances patient safety.
  • Serial ultrasonography is a valuable tool for informed decision-making regarding splenic rupture risk.