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Updated: Jan 20, 2026

Microwave-driven Synthesis of Iron Oxide Nanoparticles for Fast Detection of Atherosclerosis
Published on: March 22, 2016
Synthesis of 64Cu-Radiolabeled Folate-Conjugated Iron Oxide Nanoparticles for Cancer Diagnosis
Seungil Park1, Bo-Bae Cho2, J R Anusha1
1Department of Chemistry, Dongguk University, Jung-gu, Seoul-04620, Republic of Korea.
Abstract:
We report the synthesis of 64Cu-labeled folate-conjugated magnetic nanoparticles for positron emission tomography (PET)/magnetic resonance imaging (MRI)-based diagnosis of cancer. The citrate/hydrazine-stabilized Fe₃O₄ nanoparticles measuring ~50 nm were utilized for target synthesis. Radio-thin-layer chromatography (TLC) analysis shows the formation of 64Cu-labeled nanomaterial with a radiochemical purity of 82.17% and a stability of ~90% in buffer solution and human serum for 24 h. Moreover, the sample exhibited good cellular uptake in breast (SKBR3), oral (KB) and lung (A549) cancer cell lines.
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