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Updated: Jan 19, 2026
Calculating Formal Charges and Predicting Molecular Structures
Convergent Formal Synthesis of Ecteinascidin 743
Junhao Jia1, Ruijiao Chen2, Yuanliang Jia1
1Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry , Sichuan University , Chengdu 610064 , P.R. China.
Abstract:
A concise formal synthesis of ecteinascidin 743 is described. Key features involve the coupling of the multisubstituted tetrahydroisoquinoline and phenylalaninol moieties via a regio- and stereoselective Pictet-Spengler cyclization as well as the subsequent chemoselective MOM protection of the phenol group, which opens a rapid access to the desirable pentacycle. The synthesis successfully delivered the advanced intermediate with the characteristic macrolactone from sesamol in 23 steps.
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