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TLR4 promotes liver inflammation by activating the JNK pathway

W Li1, G-L Yang, Q Zhu

  • 1Department of Hepatology, Third People's Hospital of Shenzhen City, Shenzhen, China. gl.yang@163.com.

European Review for Medical and Pharmacological Sciences
|September 21, 2019
PubMed
Summary

Toll-like receptor 4 (TLR4) exacerbates acetaminophen-induced liver injury by activating the JNK pathway, leading to inflammation and immune cell infiltration. Inhibiting TLR4 in mice reduced liver damage, suggesting it as a therapeutic target for drug-induced hepatitis.

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