THE STUDY OF SKIN AUTOFLORA'S PATHOGENIC PROPERTIES IN PATIENTS DIAGNOSED WITH ATOPIC DERMATITIS

The development of atopic dermatitis (AD) is often associated with the presence of pathogenic microflora in the skin's biotope against the background of acute immunological disorders of the microorganism. In this case, the leading role is played by Staphylococcus aureus, which is seeded in 80-95% of patients diagnosed with AD. The clinical significance of the pathogen is determined by its ability to actively survive in the biotope, aided by a wide range of pathogenicity factors of this microorganism. Goal of research - to study the activity levels of pathogenicity factors and the persistence of staphylococci clinical autostrains isolated from different topodems of the skin of patients diagnosed with AD. The object of study was 101 laboratory strain of the skin's staphylococci of 50 patients diagnosed with AD and 39 control strains isolated from 20 generally healthy individuals. Isolation of microorganisms and bacteriological studies of their pathogenic characteristics were carried out using the methods of classical bacteriology. It was revealed that the qualitative and quantitative characteristics of the antilysocyme activity (ALA), the anti-interferon activity (AIA) and the adhesive properties of the strains isolated from the affected skin areas were significantly higher than that of the cultures isolated from the intact areas. The data obtained indicate the ability of these pathogens to adversely affect the course of the pathological process in the skin.