[Granulocyte functional characteristics of mice with transplanted tumors]

The Ehrlich ascitic carcinoma (EAC) growing subcutaneously in (CBA X C57B1)F1 mice was found to induce leukocytosis with the elevated number of mature granulocytes in the peripheral blood. At the same time depletion of the cell amount in the thymus and an increase of cells, especially granulocytic ones, in the spleen was observed. Granulocyte contamination of the ficoll-verografin gradient interphase was detected in mononuclear cells separated from tumour host blood. Simultaneously, expression of Fc G-receptors of granulocytes decreased in tumour-bearing mice. These data are discussed in terms of inhibitory effect of the EAC on granulocyte functions in the presence of paraneoplastic leukocytosis.