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Updated: Jan 5, 2026
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
Published on: October 28, 2022
Antenatal and intrapartum risk factors for neonatal hypoxic ischemic encephalopathy
Patrick J Peebles1, Theresa M Duello2, Jens C Eickhoff3
1Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. pjpeebles@wisc.edu.
Objective:
To identify antenatal and intrapartum risk factors for neonatal hypoxic ischemic encephalopathy (HIE).
Study Design:
A single center, retrospective cohort study was conducted for 25,494 singleton births ≥36 weeks' gestation born between 2009 and 2016. Univariate and multivariate analyses were performed to identify risk factors for HIE.
Results:
Thirty-seven infants met HIE inclusion criteria. Independent antenatal risk factors included primigravida, previous fetal death/stillbirth, antidepressant use, illicit drug use, Rh sensitization, and adjusted gestational weight gain >13.6 kg. Independent intrapartum risk factors identified were placental abruption, ruptured uterus, moderate-to-heavy meconium stained amniotic fluid, and delivery by cesarean-section. An intrapartum risk factor was present in 70.3% of the HIE group compared with 29.6% of the non-HIE group.
Conclusion:
Intrapartum period risk factors appear to be important for the development of HIE. Gestational weight gain may serve as an important modifiable factor to reduce the risk of HIE.
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