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[Synthetic chromosomes: rewriting the code of life]
Vincent Baby1, Fabien Labroussaa2, Carole Lartigue1
1INRA, UMR 1332 de biologie du fruit et pathologie, 71 avenue E. Bourlaux, 33140 Villenave d'Ornon, France - Univ. Bordeaux, UMR 1332 de biologie du fruit et pathologie, 71 avenue E. Bourlaux 33140 Villenave d'Ornon, France.
Abstract:
The past decade has seen vast improvements in DNA synthesis and assembly methods. The creation of synthetic DNA molecules is becoming easier and more affordable, such that entire chromosomes can now be synthesized. These advances mark the beginning of synthetic genomics, a new discipline interested in the construction of complete genomes tailored for the study and application of biological systems. From viral genome synthesis to the reconstruction of the yeast 16 chromosomes, we discuss the main discoveries, the regulations and ethical considerations along with the potential of this emerging discipline for the future.
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