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Published on: June 27, 2025
Bioactive polyketides from the mangrove endophytic fungi Phoma sp. SYSU-SK-7
Yan Chen1, Wencong Yang2, Ge Zou2
1School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China; School of Marin Sciences, Sun Yat-sen University, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China.
Abstract:
Five new polyketides, colletotric B (2), 3-hydroxy-5-methoxy-2,4,6-trimethylbenzoic acid (3), colletotric C (4), chaetochromone D (6) and 8-hydroxy-pregaliellalactone B (9), together with four known analogues (1, 5 and 7-8) were isolated from the mangrove endophytic fungus Phoma sp. SYSU-SK-7. Their structures were elucidated by analysis of extensive spectroscopic data and mass spectrometric data. Compounds 1-2 showed strong antimicrobial activity against the P. aeruginosa, MRSA and C. albicans with the MIC values in the range of 1.67-6.28 μg/ml. Furthermore, Compounds 1-5 also exhibited significant α-glucosidase inhibitory activity with the IC50 values in the range of 36.2-90.6 μM. Compound 7 was found to inhibited radical scavenging activity against DPPH with the EC50 value of 11.8 μM.
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Fungal Phylum Basidiomycota
Fungal Group Zygomycota
Bacterial Phylum Planctomycetes

