Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nociception01:44

Nociception

32.9K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
32.9K
Pain01:20

Pain

1.2K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.2K
Analgesia and Pain Management01:25

Analgesia and Pain Management

1.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.4K
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

3.8K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
3.8K
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

7.7K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
7.7K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.3K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disparities in Distress Symptoms Among Cancer Inpatients, Outpatients and Relatives Through Introducing and Evaluating Digital Distress Screening.

Psycho-oncology·2026
Same author

Integrated, Cross-Entity Information on Preventive Measures for Bowel, Breast, and Prostate Cancer: Evaluation Study of the Web Application "Prevent-Take-Up".

JMIR cancer·2025
Same author

CLL to Richter syndrome: Integrating network strategies with experiments elucidating disease drivers and personalized therapies.

Science advances·2025
Same author

Diabetic retinopathy screening using machine learning: a systematic review.

BMC biomedical engineering·2025
Same author

Deep Learning Predicts Postoperative Mobility, Activities of Daily Living, and Discharge Destination in Older Adults from Sensor Data.

Sensors (Basel, Switzerland)·2025
Same author

Uncovering the Understanding of the Concept of Patient Similarity in Cancer Research and Treatment: Scoping Review.

Journal of medical Internet research·2025
Same journal

RETRACTED: Zhang et al. A Novel Framework for Reconstruction and Imaging of Target Scattering Centers via Wide-Angle Incidence in Radar Networks. <i>Sensors</i> 2025, <i>25</i>, 6802.

Sensors (Basel, Switzerland)·2026
Same journal

Enhancing Unsupervised Multi-Source Domain Adaptation for Person Re-Identification via Mixture of Experts and Graph-Based Relation.

Sensors (Basel, Switzerland)·2026
Same journal

Development of an Instrumented Glove for Palmar Pressure Assessment in Kayakers.

Sensors (Basel, Switzerland)·2026
Same journal

Development and Experimental Validation of an Autonomous IoT-Based Monitoring System for Real-Time Water Quality Assessment in the Amazon River.

Sensors (Basel, Switzerland)·2026
Same journal

Semi-Supervised Adversarial Learning Framework for Controller Area Network Bus Intrusion Detection.

Sensors (Basel, Switzerland)·2026
Same journal

Smart Optimization Method for Safety Signs in Innovative Manufacturing Environments Integrating Industrial Field IoT Sensors and Knowledge Graphs.

Sensors (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Jan 5, 2026

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli
09:16

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Published on: April 5, 2019

11.4K

Exploring Deep Physiological Models for Nociceptive Pain Recognition.

Patrick Thiam1,2, Peter Bellmann3, Hans A Kestler4

  • 1Institute of Medical Systems Biology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. patrick.thiam@uni-ulm.de.

Sensors (Basel, Switzerland)
|October 20, 2019
PubMed
Summary
This summary is machine-generated.

Deep learning models autonomously learn features from physiological data to classify pain intensity. These novel deep neural networks outperform traditional methods for pain assessment using electrodermal activity.

Keywords:
convolutional neural networksinformation fusionpain intensity classificationsignal processing

More Related Videos

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

13.1K
Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

21.2K

Related Experiment Videos

Last Updated: Jan 5, 2026

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli
09:16

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Published on: April 5, 2019

11.4K
Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

13.1K
Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

21.2K

Area of Science:

  • Computational Neuroscience
  • Biomedical Engineering
  • Machine Learning

Background:

  • Traditional pain assessment relies on manual feature engineering and expert knowledge.
  • Deep learning offers integrated feature engineering, selection, and model optimization.
  • Previous studies often used hand-crafted features for pain intensity classification.

Purpose of the Study:

  • To design deep learning architectures for autonomous feature learning in pain intensity assessment.
  • To accurately classify different levels of induced nociceptive pain using physiological signals.
  • To outperform existing methods by leveraging deep neural networks for pain inference.

Main Methods:

  • Developed deep neural network architectures for autonomous feature learning.
  • Utilized the BioVid Heat Pain Database (Part A) for model assessment.
  • Employed Leave-One-Subject-Out (LOSO) cross-validation for robust evaluation.

Main Results:

  • Uni-modal electrodermal activity (EDA) architecture achieved 84.57% accuracy.
  • Deep fusion approaches reached 84.40% accuracy in binary classification (baseline vs. pain tolerance).
  • Proposed methods significantly outperformed previous approaches in pain intensity discrimination.

Conclusions:

  • Deep learning enables effective autonomous feature learning for pain intensity classification.
  • The proposed uni-modal and deep fusion models demonstrate superior performance.
  • The modular nature of deep neural networks facilitates transfer learning applications.