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Lopinavir-Ritonavir Impairs Adrenal Function in Infants

Dulanjalee Kariyawasam1,2,3, Marianne Peries4, Frantz Foissac5,6

  • 1Pediatric Endocrinology, Gynecology, and Diabetology Unit, Hopital Universitaire Necker-Enfants Malades, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|October 22, 2019
PubMed
Summary

Perinatal lopinavir/ritonavir (LPV/r) prophylaxis in HIV-exposed infants is linked to adrenal dysfunction, evidenced by elevated dehydroepiandrosterone (DHEA) levels. Long-term infant health impacts require further investigation.

Keywords:
CYP21 and CYP17 inhibitionHIV infant prophylaxisadrenal function impairmentlopinavir

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