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Probing the Functional Role of Physical Motion in Development
1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany; Center for Systems Biology Dresden, Germany, Germany; Cluster of Excellence, Physics of Life, TU Dresden, Dresden, Germany.
Developmental Cell
|October 23, 2019
Summary
Testing physical transport in development is challenging. New methods targeting diffusion and cytoplasmic streaming offer opportunities to validate reaction-transport models, bridging experimental physics and molecular biology.
Area of Science:
- Developmental biology
- Biophysics
- Systems biology
Background:
- Reaction-transport models are proposed to explain spatiotemporal organization during development.
- Genetic tools enable causality dissection of molecular players, but physical transport roles remain difficult to test.
Purpose of the Study:
- To explore challenges in validating reaction-transport hypotheses in developmental biology.
- To highlight new opportunities for testing physical transport mechanisms.
Main Methods:
- Review of current limitations in perturbing physical transport processes.
- Discussion of emerging perturbation approaches targeting diffusion and cytoplasmic streaming.
Main Results:
- Current methods are insufficient for testing the functional role of physical transport in development.
- New perturbation strategies provide avenues for experimental validation.
Conclusions:
- Experimental physics can advance by developing methods to test the roles of diffusion and flows in development.
- Bridging experimental physics and molecular biology is crucial for understanding developmental spatiotemporal organization.
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