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Lupus and the Liver: A Case Study.

Shaan Patel1, Michelle Demory Beckler2, Marc M Kesselman3

  • 1Miscellaneous, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.

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|October 25, 2019
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Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) can affect the liver, though it is uncommon. This case highlights lupus hepatitis in a teen with elevated liver enzymes and fatty infiltration.

Keywords:
lupuslupus hepatitissystemic lupus erythematosus (sle)

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Area of Science:

  • Rheumatology
  • Hepatology
  • Autoimmune Diseases

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with diverse systemic manifestations.
  • Hepatopathy is an uncommon manifestation of SLE, with asymptomatic hypertransaminasemia observed in up to 60% of patients.
  • Diagnosis of lupus hepatitis is typically a diagnosis of exclusion, often attributed to other causes like viral hepatitis or drug toxicity.

Observation:

  • A 15-year-old female presented with a new diagnosis of SLE.
  • Incidental elevation of liver function tests (LFTs) was noted.
  • Subsequent findings included hepatomegaly with fatty infiltration.

Findings:

  • The patient's presentation suggests a potential case of lupus hepatitis.
  • Correlation between ribosomal P autoantibodies and lupus hepatitis incidence is noted.
  • While generally responsive to prednisone, refractory cases may benefit from mycophenolate mofetil.

Implications:

  • This case underscores the importance of considering lupus hepatitis in SLE patients with unexplained liver abnormalities.
  • Early diagnosis and appropriate management are crucial for patients with SLE-related liver involvement.
  • Further research into the mechanisms and optimal treatment of lupus hepatitis is warranted.