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Calcium in Cell-Extracellular Matrix Interactions.

Sandeep Gopal1, Hinke A B Multhaupt2, John R Couchman2

  • 1Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia. sandeep.gopal@monash.edu.

Advances in Experimental Medicine and Biology
|October 25, 2019
PubMed
Summary
This summary is machine-generated.

The extracellular matrix (ECM) is a major calcium reservoir that regulates cell behavior. This chapter explores how cell-ECM interactions influence cellular calcium and how calcium mediates these crucial interactions.

Keywords:
Actin cytoskeletonCalciumCell adhesionExtracellular matrixFocal adhesionsIntegrinsMechanosensingProteoglycansSyndecansTRP channels

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Physiology

Background:

  • The extracellular matrix (ECM) is a dynamic network surrounding cells in multicellular organisms.
  • ECM serves as the largest calcium reservoir in animals and influences cell behavior.
  • Calcium is vital for ECM assembly and interacts with ECM proteins.

Purpose of the Study:

  • To investigate the role of cell-ECM interactions in cellular calcium regulation.
  • To elucidate the mechanisms by which calcium mediates cell-ECM interactions.

Main Methods:

  • Review of existing literature on ECM composition and function.
  • Analysis of studies on calcium binding to ECM proteins.
  • Examination of research on cell surface receptor interactions with ECM and calcium transport.

Main Results:

  • ECM macromolecules bind calcium, influencing its availability and cellular uptake.
  • Cell-ECM interactions trigger calcium signaling pathways.
  • Calcium modulates the structure and function of the ECM.

Conclusions:

  • Cell-ECM interactions are critical for maintaining cellular calcium homeostasis.
  • Calcium plays a dual role in regulating ECM structure and cell signaling.
  • Understanding these interactions is key to comprehending health and disease states.