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A Miniature Dual-Biomarker-Based Sensing and Conditioning Device for Closed-Loop DBS.
Mahboubeh Parastarfeizabadi1, Abbas Z Kouzani1
1School of EngineeringDeakin UniversityGeelongVIC3216Australia.
IEEE Journal of Translational Engineering in Health and Medicine
|November 1, 2019
Summary
This study introduces a miniature, dual-biomarker device for closed-loop deep brain stimulation. It simultaneously records local field potentials (LFPs) and action potentials (APs) for enhanced neural feedback control.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Implantable Devices
Background:
- Deep brain stimulation (DBS) is a therapeutic intervention for neurological disorders.
- Current DBS systems often lack sophisticated real-time feedback mechanisms.
- Sensing neural signals like LFPs and APs is crucial for adaptive DBS.
Purpose of the Study:
- To develop a compact, dual-biomarker neural sensing device.
- To enable closed-loop functionality in deep brain stimulation systems.
- To provide a tetherless platform for pre-clinical DBS research.
Main Methods:
- Designed a two-channel device measuring local field potentials (LFPs) and action potentials (APs).
- Integrated pre-amplifiers, filters, and amplifiers for signal conditioning.
- Validated the device using benchtop tests with sinusoidal and neural signals, and in-vitro tests in saline.
Main Results:
- Achieved miniature size (1.2 g, 11.2 mm diameter) and light weight.
- Demonstrated 100 dB gain for both LFP and AP channels.
- Successfully validated sensing capabilities through bench and in-vitro experiments.
Conclusions:
- The developed device concurrently senses LFPs and APs.
- It facilitates closing the feedback loop in closed-loop DBS systems.
- Offers a practical, head-mountable solution for pre-clinical trials.
