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Intestinal Injury in Heat Stroke
Nan Ye1, Tiantian Yu1, Hongxia Guo1
1Department of Military Biosafety, Army Medical University, Third Military Medical University, Chongqing, China.
The Journal of Emergency Medicine
|November 12, 2019
Summary
Heat stroke severely impacts the body, with intestinal barrier dysfunction playing a key role. Protecting the gut offers a promising therapeutic strategy for heat stroke patients.
Area of Science:
- Physiology
- Pathophysiology
- Medical Science
Background:
- Heat stroke is a critical medical emergency with high mortality.
- Intestinal epithelia barrier dysfunction is increasingly recognized in heat stroke's development.
- Targeting the gut may mitigate systemic inflammation and improve outcomes.
Purpose of the Study:
- To review the role of the intestine in heat stroke pathophysiology.
- To explore mechanisms of heat stress-induced intestinal injury.
- To summarize current and future therapeutic strategies.
Main Methods:
- Literature review of heat stroke and intestinal injury.
- Analysis of studies on gut-protective interventions.
- Synthesis of evidence on heat stress and the intestinal barrier.
Main Results:
- Heat stress directly injures the intestine, leading to barrier dysfunction.
- Impaired intestinal barrier allows endotoxin circulation, exacerbating systemic effects.
- Intestine-specific treatments show potential for managing heat stroke.
Conclusions:
- The intestine is a critical target organ in heat stroke.
- Further research into heat stroke pathogenesis is needed for novel treatments.
- Gut-protective strategies represent a promising avenue for heat stroke prevention and management.
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