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Bio Mimicking of Extracellular Matrix
Moumita Ghosh1, Michal Halperin-Sternfeld1, Lihi Adler-Abramovich2
1Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Advances in Experimental Medicine and Biology
|November 13, 2019
Summary
Biomaterials are key in regenerative medicine and tissue engineering, but the ideal material is elusive. Composite biomaterials are being developed to combine beneficial properties for enhanced tissue regeneration strategies.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Biomaterials are essential for regenerative medicine, including stem cell therapies and tissue engineering.
- Three-dimensional (3D) scaffolds made from biomaterials are crucial for creating bio-inspired replacement tissues.
- Current naturally derived and synthetic biomaterials have limitations, driving the search for ideal materials.
Purpose of the Study:
- To review structural features and performance of various biomaterials.
- To highlight applications in regenerative medicine and tissue engineering.
- To discuss the development of novel biomaterials and composite approaches.
Main Methods:
- Review of naturally derived and synthetic biomaterials.
- Analysis of composite biomaterial design and fabrication.
- Exploration of theranostic approaches in tissue engineering.
Main Results:
- No single biomaterial possesses all ideal characteristics for tissue engineering.
- Composite biomaterials offer a promising strategy by combining properties of multiple materials.
- Diverse research efforts focus on novel biomaterial development for enhanced regenerative strategies.
Conclusions:
- Biomaterials are fundamental to advancing regenerative medicine and tissue engineering.
- Composite biomaterials represent a significant advancement, overcoming limitations of single materials.
- Continued innovation in biomaterial design is critical for future therapeutic applications.
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