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Multisystem Toxicity in Cancer: Lessons from NASA's Countermeasures Program.
Jessica M Scott1, Lianne B Dolan2, Larry Norton1
1Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA.
Cell
|November 16, 2019
Summary
NASA
Area of Science:
- Spaceflight physiology
- Oncology
- Translational medicine
Background:
- Spaceflight induces multisystem physiological toxicities.
- Cancer treatments also cause significant toxicities.
- These toxicities share commonalities between astronauts and cancer patients.
Purpose of the Study:
- To propose a novel countermeasures program (CMP) modeled after NASA's spaceflight research.
- To investigate the application of spaceflight-derived strategies for mitigating cancer-related toxicities.
- To elucidate and abrogate physiological toxicities in cancer patients.
Main Methods:
- Leveraging NASA's extensive experience in characterizing and mitigating spaceflight physiological effects.
- Adapting established countermeasures for the unique challenges of cancer patient care.
- Developing a framework for a NASA-modeled CMP in oncology.
Main Results:
- The proposed CMP offers a unique approach to managing cancer treatment side effects.
- Identifies potential overlaps in physiological responses to spaceflight and cancer therapy.
- Provides a foundation for future research into novel therapeutic strategies.
Conclusions:
- A NASA-modeled CMP holds promise for improving the quality of life for cancer patients.
- Cross-disciplinary approaches can yield innovative solutions in medicine.
- Further research is warranted to validate and implement this approach.
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