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Updated: Jan 3, 2026
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Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
Published on: August 4, 2018
8.9K
Handheld Adaptive Optics Scanning Laser Ophthalmoscope.
Theodore DuBose1, Derek Nankivil1, Francesco LaRocca1
1Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Optica
|November 21, 2019
Summary
Researchers developed a portable handheld adaptive optics scanning laser ophthalmoscopy (HAOSLO) system. This miniaturized device enables in vivo retinal imaging in infants and adults, expanding AO-enhanced ophthalmoscopy applications.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Medical Imaging
Background:
- Adaptive optics scanning laser ophthalmoscopy (AOSLO) provides high-resolution in vivo retinal imaging.
- Current AOSLO systems are bulky and primarily used for adult subjects.
Purpose of the Study:
- To design and develop the first portable handheld AOSLO (HAOSLO) system.
- To miniaturize AOSLO technology for broader patient populations, including infants.
Main Methods:
- Incorporated a novel computational wavefront sensorless adaptive optics (AO) algorithm.
- Utilized custom optics for system miniaturization, achieving a weight under 200 grams.
- Employed a handheld probe for in vivo imaging.
Main Results:
- Successfully miniaturized AOSLO into a portable handheld device (HAOSLO).
- Achieved in vivo imaging of cones near the fovea in adults using the HAOSLO.
- Obtained the first AO-enhanced images of infant cones.
Conclusions:
- The portable HAOSLO system significantly expands the accessibility of AO-enhanced retinal imaging.
- This technology facilitates in vivo visualization of retinal structures in new patient populations, including infants.
- HAOSLO represents a breakthrough in ophthalmic imaging for pediatric and broader clinical applications.
