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High Sensitivity 5-hydroxymethylcytosine Detection in Balb/C Brain Tissue
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Highly sensitive quantification of site-specific 5-hydroxymethylcytosine at single-base resolution by HpaII-mediated
Zhenhao Zhang1, Xiao Shan1, Pengbo Zhang2
1Key laboratory of Applied Surface and Colloid Chemistry Ministry of Education, Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, Shaanxi Province, P. R. China. lzpbd@snnu.edu.cn yanjingli@snnu.edu.cn.
Organic & Biomolecular Chemistry
|November 21, 2019
Abstract:
A highly sensitive HpaII-mediated ligation PCR assay that can precisely discriminate 5hmC from 5mC and C is developed for the quantitative determination of site-specific 5hmC in genomic DNA samples.
